We are less confident in the accuracy results for the Falcivax Device Rapid test, because these came from only two studies. The results are from a small number of studies (four), so our findings may change when results from further studies become available. We are moderately confident (certain) in the accuracy results for the Care Start Malaria Pf/Pv Combo test. for every 100 people tested who do not have P vivax malaria, one person will have a positive result.For every 100 people tested who have P vivax malaria, 23 people will have a negative test result and,.for every 100 people tested who do not have P vivax malaria, one will have a positive result, and might receive unnecessary treatment.Ĭompared with microscopy, the Falcivax Device Rapid test had a sensitivity of 77% and a specificity of 99% (two studies).for every 100 people tested who have P vivax malaria, one person will have a negative test result, and might not receive the right treatment soon enough.The studies were conducted in Ethiopia (four studies), India (two studies) and Bangladesh, Brazil, Colombia, and Sudan (one study each).Ĭompared with microscopy, the Care Start Malaria Pf/Pv Combo test performed well with 99% sensitivity and specificity (four studies). We included 10 studies that looked at the accuracy of six diagnostic test brands for detecting P vivax malaria in people with suspected malaria symptoms. We compared the new tests against the standard form of diagnosis with microscopy, and also more recent methods polymerase chain reaction (PCR): a molecular method to identify P vivax DNA in blood samples. We wanted to find out which brands of RDTs were the most accurate for diagnosing P vivax malaria. Healthcare workers in rural areas can perform RDTs for P vivax without needing a laboratory or special equipment. They are suitable for use in rural settings by primary healthcare workers, using drop of blood on the dipstick that causes colour change and a distinct line that indicates a positive test result. RDTs are simple to use, point-of-care tests. We studied RDTs that specifically test for P vivax malaria. RDTs provide results quickly and are often as a dipstick. For public health control of malaria, we know that P falciparum is declining over the previous 15 years, and infections from P vivax have therefore increased in importance. For P vivax infection, an additional drug is required to eliminate the infection from the liver. Why are rapid tests for P vivax malaria important?įor clinical management, knowing which parasite species is causing the malaria is important as the drug treatments differ. ![]() The aim of this review was to evaluate rapid diagnostic tests (RDTs) to diagnose P vivax infection. Development of an algorithm for program managers to use to best estimate national prevalence given the available diagnostic data would be useful for the future.Malaria infection is caused mainly by two species of malaria parasite: Plasmodium falciparum and Plasmodium vivax. Although results of these tests could be useful in identification of high-risk populations for targeting of interventions, assessments of impact based on changes in malaria prevalence measured with these tests are more problematic. Given the lack of a gold standard diagnostic test for malaria that is practical for use in national survey settings, discrepancies in prevalence estimates generated from microscopy testing and from RDT testing are difficult to reconcile. Although prevalence estimates from the two tests were highly correlated, RDT prevalence estimates were higher than microscopy prevalence estimates in 19 of 22 surveys examined. ![]() Prevalence estimates from 22 surveys containing both microscopy and RDT results were compared using tests of agreement, and factors that could be influencing discordance between the two tests were identified. ![]() This report examines the relationship between two different diagnostic tests used in nationally-representative household surveys to measure malaria parasitemia prevalence: Rapid Diagnostic Tests (RDTs) and microscopy.
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